49,389 XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Laura Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 25,000 | 25,000 | - | - | Restricted Stock Units | |
| Robin Toft | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 25,000 | 25,000 | - | - | Restricted Stock Units | |
| Ninfa Saunders M. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 25,000 | 25,000 | - | - | Restricted Stock Units | |
| Seymour Liebman E. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 25,000 | 25,000 | - | - | Restricted Stock Units | |
| J. John Sperzel | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 490,000 | 490,000 | - | - | Restricted Stock Units | |
| Giffin Brett A. | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 180,000 | 180,000 | - | - | Restricted Stock Units | |
| David Elsbree B. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 25,000 | 25,000 | - | - | Restricted Stock Units | |
| M. John Sprague | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 180,000 | 180,000 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 190,000 | 190,000 | - | - | Restricted Stock Units | |
| M. John Sprague | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 180,000 | 180,000 | - | - | Restricted Stock Units | |
| Gibbs Michael Terrence | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 190,000 | 190,000 | - | - | Restricted Stock Units | |
| Brett A. Giffin | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 180,000 | 180,000 | - | - | Restricted Stock Units | |
| John Cumming W. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 35,000 | 35,000 | - | - | Restricted Stock Units | |
| Sperzel John J. | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 490,000 | 490,000 | - | - | Restricted Stock Units | |
| David B. Elsbree | Director | Sale of securities on an exchange or to another person at price $ 2.42 per share. | 13 Sep 2024 | 55 | 23 (0%) | 0% | 2.4 | 133 | Common Stock |
| John J. Sperzel | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2024 | 67 | 400 (0%) | 0% | - | Common Stock | |
| Terrence Michael Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2024 | 29 | 0 | - | - | Restricted Stock Units | |
| M. John Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2024 | 29 | 0 | - | - | Restricted Stock Units | |
| Terrence Michael Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2024 | 29 | 135 (0%) | 0% | - | Common Stock | |
| John Sprague M. | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2024 | 29 | 141 (0%) | 0% | - | Common Stock | |
| John J. Sperzel | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2024 | 67 | 0 | - | - | Restricted Stock Units | |
| A. Giffin Brett | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2024 | 13 | 13 | - | - | Restricted Stock Units | |
| J. Sperzel John | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 160 | 333 (0%) | 0% | - | Common Stock | |
| Giffin Brett A. | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 13 | 77 (0%) | 0% | - | Common Stock | |
| Gibbs Terrence Michael | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 40 | 40 | - | - | Restricted Stock Units | |
| John Sperzel J. | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 160 | 160 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 40 | 106 (0%) | 0% | - | Common Stock | |
| M. John Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 40 | 112 (0%) | 0% | - | Common Stock | |
| John Sprague M. | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2024 | 40 | 40 | - | - | Restricted Stock Units | |
| Toft Robin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 6,369 | 6,369 | - | - | Restricted Stock Units | |
| Robin Toft | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2023 | 454 | 0 | - | - | Restricted Stock Units | |
| Robin Toft | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2023 | 454 | 3,472 (0%) | 0% | - | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 0.48 per share. | 28 Mar 2023 | 239 | 6,612 (0%) | 0% | 0.5 | 115 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 334 | 6,851 (0%) | 0% | - | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 334 | 0 | - | - | Restricted Stock Units | |
| John J. Sperzel | Director, Chairman and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 16,000 | 20,435 (0%) | 0% | - | Common Stock | |
| John J. Sperzel | Director, Chairman and CEO | Sale of securities on an exchange or to another person at price $ 0.59 per share. | 20 Feb 2023 | 2,898 | 17,329 (0%) | 0% | 0.6 | 1,710 | Common Stock |
| John J. Sperzel | Director, Chairman and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 6,667 | 6,667 | - | - | Restricted Stock Units | |
| John J. Sperzel | Director, Chairman and CEO | Sale of securities on an exchange or to another person at price $ 0.65 per share. | 20 Feb 2023 | 6,875 | 13,560 (0%) | 0% | 0.7 | 4,469 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 2,914 | 8,102 (0%) | 0% | - | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 0.59 per share. | 20 Feb 2023 | 1,585 | 6,517 (0%) | 0% | 0.6 | 935 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 4,000 | 8,000 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 2,914 | 2,914 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 4,000 | 7,333 (0%) | 0% | - | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 0.65 per share. | 20 Feb 2023 | 2,145 | 5,188 (0%) | 0% | 0.6 | 1,394 | Common Stock |
| John M. Sprague | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.65 per share. | 20 Feb 2023 | 1,545 | 5,502 (0%) | 0% | 0.6 | 1,004 | Common Stock |
| John M. Sprague | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.59 per share. | 20 Feb 2023 | 1,148 | 7,268 (0%) | 0% | 0.6 | 677 | Common Stock |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 4,000 | 8,000 | - | - | Restricted Stock Units | |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 2,914 | 2,914 | - | - | Restricted Stock Units | |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 4,000 | 7,047 (0%) | 0% | - | Common Stock | |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 2,914 | 8,416 (0%) | 0% | - | Common Stock | |
| Brett A. Giffin | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 1,333 | 1,378 (0%) | 0% | - | Common Stock | |
| Brett A. Giffin | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 0.65 per share. | 20 Feb 2023 | 537 | 841 (0%) | 0% | 0.6 | 349 | Common Stock |
| Brett A. Giffin | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 1,333 | 2,667 | - | - | Restricted Stock Units | |
| John J. Sperzel | Director, Chairman and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 16,000 | 32,000 | - | - | Restricted Stock Units | |
| John J. Sperzel | Director, Chairman and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2023 | 6,667 | 20,227 (0%) | 0% | - | Common Stock | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2023 | 1,550 | 0 | - | - | Restricted Stock Units | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2023 | 1,550 | 4,568 (0%) | 0% | - | Common Stock | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2023 | 454 | 5,022 (0%) | 0% | - | Common Stock | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2023 | 454 | 0 | - | - | Restricted Stock Units | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2023 | 1,550 | 0 | - | - | Restricted Stock Units | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2023 | 454 | 5,022 (0%) | 0% | - | Common Stock | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2023 | 1,550 | 4,568 (0%) | 0% | - | Common Stock | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2023 | 454 | 0 | - | - | Restricted Stock Units | |
| Brett A. Giffin | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 1.79 per share. | 08 Nov 2022 | 1,292 | 2,253 (0%) | 0% | 1.8 | 2,317 | Common Stock |
| Brett A. Giffin | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Nov 2022 | 3,333 | 6,667 | - | - | Restricted Stock Units | |
| Brett A. Giffin | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Nov 2022 | 3,333 | 3,545 (0%) | 0% | - | Common Stock | |
| Laura Adams | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Oct 2022 | 732 | 732 (0%) | 0% | - | Common Stock | |
| Laura Adams | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Oct 2022 | 732 | 1,464 | - | - | Restricted Stock Units | |
| David B. Elsbree | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Oct 2022 | 115,000 | 115,000 | - | - | Restricted Stock Units | |
| John W. Cumming | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Oct 2022 | 130,000 | 130,000 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Oct 2022 | 115,000 | 115,000 | - | - | Restricted Stock Units | |
| Thierry Bernard | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Oct 2022 | 115,000 | 115,000 | - | - | Restricted Stock Units | |
| Ninfa M. Saunders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Oct 2022 | 115,000 | 115,000 | - | - | Restricted Stock Units | |
| Robin Toft | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Oct 2022 | 115,000 | 115,000 | - | - | Restricted Stock Units | |
| Laura Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Oct 2022 | 115,000 | 115,000 | - | - | Restricted Stock Units | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2022 | 22,727 | 22,727 | - | - | Restricted Stock Units | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2022 | 22,727 | 150,936 (0%) | 0% | - | Common Stock | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2022 | 22,727 | 150,936 (0%) | 0% | - | Common Stock | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2022 | 22,727 | 22,727 | - | - | Restricted Stock Units | |
| Robin Toft | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2022 | 22,727 | 150,936 (0%) | 0% | - | Common Stock | |
| Robin Toft | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2022 | 22,727 | 22,727 | - | - | Restricted Stock Units | |
| David B. Elsbree | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 73,224 | 0 | - | - | Restricted Stock Units | |
| David B. Elsbree | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 73,224 | 276,205 (0%) | 0% | - | Common Stock | |
| John W. Cumming | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 81,967 | 132,819 (0%) | 0% | - | Common Stock | |
| John W. Cumming | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 81,967 | 0 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 73,224 | 235,121 (0%) | 0% | - | Common Stock | |
| Seymour E. Liebman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 73,224 | 0 | - | - | Restricted Stock Units | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 73,224 | 128,209 (0%) | 0% | - | Common Stock | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 73,224 | 0 | - | - | Restricted Stock Units | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 73,224 | 0 | - | - | Restricted Stock Units | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 73,224 | 128,209 (0%) | 0% | - | Common Stock | |
| Robin Toft | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 73,224 | 0 | - | - | Restricted Stock Units | |
| Robin Toft | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2022 | 73,224 | 128,209 (0%) | 0% | - | Common Stock | |
| John M. Sprague | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.48 per share. | 08 Apr 2022 | 10,000 | 152,350 (0%) | 0% | 0.5 | 4,767 | Common Stock |
| Alec Barclay | Chief Operations Officer | Purchase of securities on an exchange or from another person at price $ 0.50 per share. | 08 Apr 2022 | 12,951 | 181,944 (0%) | 0% | 0.5 | 6,476 | Common Stock |
| Brett A. Giffin | Chief Commercial Officer | Purchase of securities on an exchange or from another person at price $ 0.49 per share. | 08 Apr 2022 | 10,600 | 10,600 (0%) | 0% | 0.5 | 5,183 | Common Stock |
| John J. Sperzel | Director, Chairman, CEO, and President | Purchase of securities on an exchange or from another person at price $ 0.50 per share. | 07 Apr 2022 | 30,000 | 221,773 (0%) | 0% | 0.5 | 15,000 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Purchase of securities on an exchange or from another person at price $ 0.49 per share. | 07 Apr 2022 | 10,000 | 166,651 (0%) | 0% | 0.5 | 4,900 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2022 | 16,666 | 16,667 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2022 | 16,666 | 165,441 (0%) | 0% | - | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.44 per share. | 24 Mar 2022 | 8,790 | 156,651 (0%) | 0% | 0.4 | 3,876 | Common Stock |
| Alec Barclay | Chief Operations Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2022 | 21,666 | 21,667 | - | - | Restricted Stock Units | |
| Alec Barclay | Chief Operations Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2022 | 21,666 | 180,421 (0%) | 0% | - | Common Stock | |
| Alec Barclay | Chief Operations Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.36 per share. | 14 Mar 2022 | 11,428 | 168,993 (0%) | 0% | 0.4 | 4,160 | Common Stock |
| Brett A. Giffin | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2022 | 500,000 | 500,000 | - | - | Restricted Stock Units | |
| John J. Sperzel | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2022 | 333,333 | 333,333 (0%) | 0% | - | Common Stock | |
| John J. Sperzel | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2022 | 333,333 | 666,667 | - | - | Restricted Stock Units | |
| John J. Sperzel | Director, See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.45 per share. | 24 Feb 2022 | 141,560 | 191,773 (0%) | 0% | 0.4 | 63,532 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.45 per share. | 24 Feb 2022 | 76,867 | 148,775 (0%) | 0% | 0.4 | 34,498 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2022 | 145,719 | 291,439 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2022 | 145,719 | 225,642 (0%) | 0% | - | Common Stock | |
| John M. Sprague | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.45 per share. | 24 Feb 2022 | 55,008 | 142,350 (0%) | 0% | 0.4 | 24,688 | Common Stock |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2022 | 145,719 | 197,358 (0%) | 0% | - | Common Stock | |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2022 | 145,719 | 291,439 | - | - | Restricted Stock Units | |
| Alec Barclay | Chief Operations Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.45 per share. | 24 Feb 2022 | 88,878 | 158,755 (0%) | 0% | 0.4 | 39,888 | Common Stock |
| Alec Barclay | Chief Operations Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2022 | 168,488 | 336,976 | - | - | Restricted Stock Units | |
| Alec Barclay | Chief Operations Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2022 | 168,488 | 247,633 (0%) | 0% | - | Common Stock | |
| John J. Sperzel | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2022 | 2,400,000 | 2,400,000 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2022 | 10,000 | 0 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2022 | 10,000 | 85,198 (0%) | 0% | - | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.47 per share. | 20 Feb 2022 | 5,275 | 79,923 (0%) | 0% | 0.5 | 2,458 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2022 | 600,000 | 600,000 | - | - | Restricted Stock Units | |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2022 | 10,000 | 0 | - | - | Restricted Stock Units | |
| John M. Sprague | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2022 | 600,000 | 600,000 | - | - | Restricted Stock Units | |
| John M. Sprague | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.47 per share. | 20 Feb 2022 | 3,775 | 51,639 (0%) | 0% | 0.5 | 1,759 | Common Stock |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2022 | 10,000 | 55,414 (0%) | 0% | - | Common Stock | |
| Alec Barclay | Chief Operations Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.47 per share. | 20 Feb 2022 | 5,275 | 79,145 (0%) | 0% | 0.5 | 2,458 | Common Stock |
| Alec Barclay | Chief Operations Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2022 | 10,000 | 0 | - | - | Restricted Stock Units | |
| Alec Barclay | Chief Operations Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2022 | 600,000 | 600,000 | - | - | Restricted Stock Units | |
| Alec Barclay | Chief Operations Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2022 | 10,000 | 84,420 (0%) | 0% | - | Common Stock | |
| Aparna Ahuja | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2022 | 600,000 | 600,000 | - | - | Restricted Stock Units | |
| Brett A. Giffin | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2022 | 200,000 | 200,000 | - | - | Restricted Stock Units | |
| Aparna Ahuja | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 0.48 per share. | 06 Jan 2022 | 61,988 | 107,611 (0%) | 0% | 0.5 | 29,754 | Common Stock |
| Aparna Ahuja | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2022 | 153,664 | 169,599 (0%) | 0% | - | Common Stock | |
| Aparna Ahuja | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2022 | 153,664 | 307,328 | - | - | Restricted Stock Units | |
| David B. Elsbree | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2022 | 32,258 | 202,981 (0%) | 0% | - | Common Stock | |
| David B. Elsbree | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2022 | 32,258 | 0 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2022 | 77,519 | 77,519 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2022 | 32,258 | 161,897 (0%) | 0% | - | Common Stock | |
| Seymour E. Liebman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2022 | 32,258 | 0 | - | - | Restricted Stock Units | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2022 | 32,258 | 54,985 (0%) | 0% | - | Common Stock | |
| Thierry Bernard | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2022 | 77,519 | 77,519 | - | - | Restricted Stock Units | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2022 | 32,258 | 0 | - | - | Restricted Stock Units | |
| Ninfa M. Saunders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2022 | 77,519 | 77,519 | - | - | Restricted Stock Units | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2022 | 32,258 | 0 | - | - | Restricted Stock Units | |
| Robin Toft | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2022 | 32,258 | 0 | - | - | Restricted Stock Units | |
| Robin Toft | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2022 | 32,258 | 54,985 (0%) | 0% | - | Common Stock | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2022 | 32,258 | 54,985 (0%) | 0% | - | Common Stock | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2021 | 22,727 | 22,727 (0%) | 0% | - | Common Stock | |
| Thierry Bernard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2021 | 22,727 | 45,454 | - | - | Restricted Stock Units | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2021 | 22,727 | 45,454 | - | - | Restricted Stock Units | |
| Ninfa M. Saunders | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2021 | 22,727 | 22,727 (0%) | 0% | - | Common Stock | |
| Robin Toft | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2021 | 22,727 | 22,727 (0%) | 0% | - | Common Stock | |
| Robin Toft | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2021 | 22,727 | 45,454 | - | - | Restricted Stock Units | |
| John W. Cumming | Director | Sale of securities on an exchange or to another person at price $ 1.16 per share. | 01 Jul 2021 | 18,182 | 50,852 (0%) | 0% | 1.2 | 21,091 | Common Stock |
| John McDonough | Director | Sale of securities on an exchange or to another person at price $ 1.16 per share. | 01 Jul 2021 | 18,182 | 516,386 (1%) | 0% | 1.2 | 21,091 | Common Stock |
| David B. Elsbree | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2021 | 73,224 | 73,224 | - | - | Restricted Stock Units | |
| David B. Elsbree | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2021 | 45,454 | 170,723 (0%) | 0% | - | Common Stock | |
| David B. Elsbree | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2021 | 45,454 | 45,454 | - | - | Restricted Stock Units | |
| John W. Cumming | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2021 | 45,454 | 69,034 (0%) | 0% | - | Common Stock | |
| John W. Cumming | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2021 | 81,967 | 81,967 | - | - | Restricted Stock Units | |
| John W. Cumming | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2021 | 45,454 | 45,454 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2021 | 73,224 | 73,224 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2021 | 45,454 | 45,454 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2021 | 45,454 | 129,639 (0%) | 0% | - | Common Stock | |
| John McDonough | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2021 | 81,967 | 81,967 | - | - | Restricted Stock Units | |
| John McDonough | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2021 | 45,454 | 534,568 (1%) | 0% | - | Common Stock | |
| John McDonough | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2021 | 45,454 | 45,454 | - | - | Restricted Stock Units | |
| Thierry Bernard | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2021 | 73,224 | 73,224 | - | - | Restricted Stock Units | |
| Ninfa M. Saunders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2021 | 73,224 | 73,224 | - | - | Restricted Stock Units | |
| Robin Toft | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2021 | 73,224 | 73,224 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2021 | 16,667 | 33,333 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 1.56 per share. | 24 Mar 2021 | 8,758 | 73,256 (0%) | 0% | 1.6 | 13,662 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2021 | 16,667 | 82,014 (0%) | 0% | - | Common Stock | |
| Anthony Pare | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 1.84 per share. | 17 Mar 2021 | 9,620 | 31,612 (0%) | 0% | 1.8 | 17,701 | Common Stock |
| Alec Barclay | Chief Operations Officer | Sale of securities on an exchange or to another person at price $ 1.86 per share. | 17 Mar 2021 | 12,494 | 74,420 (0%) | 0% | 1.9 | 23,239 | Common Stock |
| Anthony Pare | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2021 | 17,500 | 35,000 | - | - | Restricted Stock Units | |
| Anthony Pare | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2021 | 17,500 | 41,232 (0%) | 0% | - | Common Stock | |
| Alec Barclay | Chief Operations Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2021 | 21,667 | 43,333 | - | - | Restricted Stock Units | |
| Alec Barclay | Chief Operations Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2021 | 21,667 | 86,914 (0%) | 0% | - | Common Stock | |
| Anthony Pare | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 505,464 | 505,464 | - | - | Restricted Stock Units | |
| John J. Sperzel | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 1,000,000 | 1,000,000 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 437,158 | 437,158 | - | - | Restricted Stock Units | |
| John M. Sprague | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 437,158 | 437,158 | - | - | Restricted Stock Units | |
| Alec Barclay | Chief Operations Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 505,464 | 505,464 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2021 | 10,000 | 72,627 (0%) | 0% | - | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2021 | 10,000 | 10,000 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 2.06 per share. | 21 Feb 2021 | 7,280 | 65,347 (0%) | 0% | 2.1 | 14,997 | Common Stock |
| John M. Sprague | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 2.04 per share. | 21 Feb 2021 | 5,250 | 35,485 (0%) | 0% | 2.0 | 10,710 | Common Stock |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2021 | 10,000 | 10,000 | - | - | Restricted Stock Units | |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2021 | 10,000 | 40,735 (0%) | 0% | - | Common Stock | |
| Alec Barclay | Chief Operations Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2021 | 10,000 | 72,527 (0%) | 0% | - | Common Stock | |
| Alec Barclay | Chief Operations Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2021 | 10,000 | 10,000 | - | - | Restricted Stock Units | |
| Alec Barclay | Chief Operations Officer | Sale of securities on an exchange or to another person at price $ 2.06 per share. | 21 Feb 2021 | 7,280 | 65,247 (0%) | 0% | 2.1 | 14,997 | Common Stock |
| Aparna Ahuja | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2021 | 460,992 | 460,992 | - | - | Restricted Stock Units | |
| David B. Elsbree | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2021 | 34,188 | 125,269 (0%) | 0% | - | Common Stock | |
| David B. Elsbree | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2021 | 34,188 | 34,188 | - | - | Restricted Stock Units | |
| David B. Elsbree | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 32,258 | 32,258 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2021 | 34,188 | 34,188 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 32,258 | 32,258 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2021 | 34,188 | 84,185 (0%) | 0% | - | Common Stock | |
| Thierry Bernard | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 32,258 | 32,258 | - | - | Restricted Stock Units | |
| Ninfa M. Saunders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 32,258 | 32,258 | - | - | Restricted Stock Units | |
| Robin Toft | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 32,258 | 32,258 | - | - | Restricted Stock Units | |
| David B. Elsbree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 45,454 | 45,454 | - | - | Restricted Stock Units | |
| John W. Cumming | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 45,454 | 45,454 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 45,454 | 45,454 | - | - | Restricted Stock Units | |
| John McDonough | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 45,454 | 45,454 | - | - | Restricted Stock Units | |
| Thierry Bernard | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 68,181 | 68,181 | - | - | Restricted Stock Units | |
| Ninfa Saunders | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 68,181 | 68,181 | - | - | Restricted Stock Units | |
| Robin Toft | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 68,181 | 68,181 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2020 | 50,000 | 50,000 | - | - | Restricted Stock Units | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2020 | 90,000 | 90,000 | - | - | Restricted Stock Units | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2020 | 180,000 | 180,000 | - | - | Stock Option (Right to Buy) | |
| Alec Barclay | SVP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2020 | 130,000 | 130,000 | - | - | Stock Option (Right to Buy) | |
| Alec Barclay | SVP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2020 | 65,000 | 65,000 | - | - | Restricted Stock Units | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2020 | 10,000 | 74,802 (0%) | 0% | - | Common Stock | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2020 | 10,000 | 20,000 | - | - | Restricted Stock Units | |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.82 per share. | 21 Feb 2020 | 5,808 | 68,994 (0%) | 0% | 0.8 | 4,763 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2020 | 10,000 | 66,587 (0%) | 0% | - | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2020 | 10,000 | 20,000 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 0.82 per share. | 21 Feb 2020 | 5,808 | 60,779 (0%) | 0% | 0.8 | 4,763 | Common Stock |
| John M. Sprague | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.82 per share. | 21 Feb 2020 | 4,166 | 22,222 (0%) | 0% | 0.8 | 3,416 | Common Stock |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2020 | 10,000 | 26,388 (0%) | 0% | - | Common Stock | |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2020 | 10,000 | 20,000 | - | - | Restricted Stock Units | |
| Alec Barclay | SVP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2020 | 10,000 | 52,102 (0%) | 0% | - | Common Stock | |
| Alec Barclay | SVP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2020 | 10,000 | 20,000 | - | - | Restricted Stock Units | |
| Alec Barclay | SVP, Operations | Sale of securities on an exchange or to another person at price $ 0.82 per share. | 21 Feb 2020 | 5,808 | 46,294 (0%) | 0% | 0.8 | 4,763 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.77 per share. | 09 Feb 2020 | 3,200 | 64,802 (0%) | 0% | 0.8 | 2,464 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2020 | 5,833 | 68,002 (0%) | 0% | - | Common Stock | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2020 | 5,833 | 0 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2020 | 5,833 | 0 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2020 | 5,833 | 59,787 (0%) | 0% | - | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 0.77 per share. | 09 Feb 2020 | 3,200 | 56,587 (0%) | 0% | 0.8 | 2,464 | Common Stock |
| John McDonough | None | Sale of securities on an exchange or to another person at price $ 1.15 per share. | 23 Jan 2020 | 57,417 | 512,868 (1%) | 0% | 1.2 | 66,030 | Common Stock |
| John McDonough | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jan 2020 | 100,000 | 570,285 (1%) | 0% | - | Common Stock | |
| John McDonough | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jan 2020 | 100,000 | 0 | - | - | Restricted Stock Units | |
| John McDonough | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jan 2020 | 16,666 | 0 | - | - | Restricted Stock Units | |
| John McDonough | None | Sale or transfer of securities back to the company at price $ 0.00 per share. | 08 Jan 2020 | 326,087 | 0 | - | - | Performance Restricted Stock Units | |
| John McDonough | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jan 2020 | 16,666 | 470,285 (0%) | 0% | - | Common Stock | |
| David B. Elsbree | None | Sale of securities on an exchange or to another person at price $ 1.16 per share. | 03 Jan 2020 | 5,316 | 91,081 (0%) | 0% | 1.2 | 6,167 | Common Stock |
| Adrian M. Jones | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2020 | 34,188 | 4,270,641 (8%) | 0% | 0 | Common Stock | |
| David B. Elsbree | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2020 | 13,289 | 13,289 | - | - | Restricted Stock Units | |
| David B. Elsbree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 34,188 | 34,188 | - | - | Restricted Stock Units | |
| David B. Elsbree | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2020 | 13,289 | 96,397 (0%) | 0% | - | Common Stock | |
| Seymour E. Liebman | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2020 | 13,289 | 13,289 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 34,188 | 34,188 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2020 | 13,289 | 50 (0%) | 0% | - | Common Stock | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Sep 2019 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Sep 2019 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| John M. Sprague | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Sep 2019 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Alec Barclay | SVP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Sep 2019 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Alec Barclay | SVP, Operations | Sale of securities on an exchange or to another person at price $ 2.92 per share. | 10 Sep 2019 | 4,210 | 42,102 (0%) | 0% | 2.9 | 12,293 | Common Stock |
| Alec Barclay | SVP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2019 | 10,000 | 46,312 (0%) | 0% | - | Common Stock | |
| David B. Elsbree | None | Sale of securities on an exchange or to another person at price $ 1.44 per share. | 11 Jun 2019 | 3,600 | 83,108 (0%) | 0% | 1.4 | 5,184 | Common Stock |
| John W. Cumming | None | Sale of securities on an exchange or to another person at price $ 1.43 per share. | 11 Jun 2019 | 3,420 | 23,580 (0%) | 0% | 1.4 | 4,891 | Common Stock |
| Stanley N. Lapidus | None | Sale of securities on an exchange or to another person at price $ 1.44 per share. | 11 Jun 2019 | 9,000 | 53,010 (0%) | 0% | 1.4 | 12,960 | Common Stock |
| Michael J. Cima | None | Sale of securities on an exchange or to another person at price $ 1.43 per share. | 11 Jun 2019 | 3,240 | 213,178 (0%) | 0% | 1.4 | 4,633 | Common Stock |
| David B. Elsbree | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2019 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| David B. Elsbree | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2019 | 9,000 | 86,708 (0%) | 0% | - | Common Stock | |
| David B. Elsbree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2019 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| John W. Cumming | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2019 | 9,000 | 27,000 (0%) | 0% | - | Common Stock | |
| John W. Cumming | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2019 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| John W. Cumming | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2019 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2019 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2019 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Seymour E. Liebman | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2019 | 9,000 | 36,708 (0%) | 0% | - | Common Stock | |
| Stanley N. Lapidus | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2019 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Stanley N. Lapidus | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2019 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Stanley N. Lapidus | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2019 | 9,000 | 62,010 (0%) | 0% | - | Common Stock | |
| Adrian M. Jones | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2019 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Michael J. Cima | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2019 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Michael J. Cima | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2019 | 9,000 | 216,418 (0%) | 0% | - | Common Stock | |
| Michael J. Cima | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2019 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| John McDonough | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2019 | 100,000 | 100,000 | - | - | Restricted Stock Units | |
| John McDonough | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2019 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2019 | 30,000 | 30,000 | - | - | Restricted Stock Units | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2019 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2019 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2019 | 30,000 | 30,000 | - | - | Restricted Stock Units | |
| John M. Sprague | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2019 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| John M. Sprague | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2019 | 30,000 | 30,000 | - | - | Restricted Stock Units | |
| Alec Barclay | SVP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2019 | 30,000 | 30,000 | - | - | Restricted Stock Units | |
| Alec Barclay | SVP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2019 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| John McDonough | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2019 | 16,666 | 456,354 (0%) | 0% | - | Common Stock | |
| John McDonough | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2019 | 16,666 | 16,667 | - | - | Restricted Stock Units | |
| John McDonough | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 3.36 per share. | 09 Feb 2019 | 8,134 | 448,220 (0%) | 0% | 3.4 | 27,330 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2019 | 5,834 | 5,833 | - | - | Restricted Stock Units | |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 3.36 per share. | 09 Feb 2019 | 3,005 | 69,704 (0%) | 0% | 3.4 | 10,097 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2019 | 5,834 | 72,709 (0%) | 0% | - | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 3.36 per share. | 09 Feb 2019 | 3,005 | 57,237 (0%) | 0% | 3.4 | 10,097 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2019 | 5,834 | 5,833 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2019 | 5,834 | 60,262 (0%) | 0% | - | Common Stock | |
| David B. Elsbree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2019 | 13,289 | 13,289 | - | - | Restricted Stock Units | |
| David B. Elsbree | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2019 | 9,708 | 9,708 | - | - | Restricted Stock Units | |
| David B. Elsbree | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2019 | 9,708 | 77,708 (0%) | 0% | - | Common Stock | |
| Seymour E. Liebman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2019 | 13,289 | 13,289 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2019 | 9,708 | 27,708 (0%) | 0% | - | Common Stock | |
| Seymour E. Liebman | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jan 2019 | 9,708 | 9,708 | - | - | Restricted Stock Units | |
| Adrian M. Jones | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2019 | 13,289 | 4,236,453 (8%) | 0% | 0 | Common Stock | |
| Stanley N. Lapidus | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 06 Nov 2018 | 27,058 | 59,058 (0%) | 0% | 1.2 | 31,387 | Common Stock |
| Stanley N. Lapidus | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Nov 2018 | 27,058 | 0 | - | - | Stock Option (Right to Buy) | |
| Stanley N. Lapidus | None | Sale of securities on an exchange or to another person at price $ 5.29 per share. | 06 Nov 2018 | 6,048 | 53,010 (0%) | 0% | 5.3 | 31,994 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share. | 20 Sep 2018 | 16,602 | 91,431 (0%) | 0% | 3.2 | 53,458 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Sep 2018 | 31,603 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 6.18 per share. | 20 Sep 2018 | 48,205 | 43,226 (0%) | 0% | 6.2 | 297,907 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share. | 20 Sep 2018 | 31,603 | 74,829 (0%) | 0% | 3.2 | 101,762 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Sep 2018 | 16,602 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.31 per share. | 18 Sep 2018 | 18,588 | 76,461 (0%) | 0% | 1.3 | 24,350 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 18 Sep 2018 | 14,647 | 57,873 (0%) | 0% | 1.2 | 16,991 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 6.14 per share. | 18 Sep 2018 | 14,647 | 128,821 (0%) | 0% | 6.1 | 89,933 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 6.20 per share. | 18 Sep 2018 | 37,902 | 43,226 (0%) | 0% | 6.2 | 234,992 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share. | 18 Sep 2018 | 27,499 | 81,128 (0%) | 0% | 3.2 | 88,547 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.25 per share. | 18 Sep 2018 | 10,403 | 53,629 (0%) | 0% | 2.3 | 23,407 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 6.17 per share. | 18 Sep 2018 | 85,595 | 43,226 (0%) | 0% | 6.2 | 528,121 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.25 per share. | 18 Sep 2018 | 1,361 | 143,468 (0%) | 0% | 2.2 | 3,062 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.45 per share. | 18 Sep 2018 | 36,235 | 142,107 (0%) | 0% | 2.5 | 88,776 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.96 per share. | 18 Sep 2018 | 29,411 | 105,872 (0%) | 0% | 2.0 | 57,646 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2018 | 14,647 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2018 | 18,588 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2018 | 29,411 | 0 | - | - | (Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2018 | 36,235 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2018 | 1,361 | 10,403 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2018 | 10,403 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2018 | 27,499 | 31,603 | - | - | Stock Option (Right to Buy) | |
| Alec Barclay | SVP, Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.49 per share. | 11 Sep 2018 | 3,522 | 33,633 (0%) | 0% | 6.5 | 22,858 | Common Stock |
| Alec Barclay | SVP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2018 | 10,000 | 37,155 (0%) | 0% | 0 | Common Stock | |
| Alec Barclay | SVP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2018 | 10,000 | 10,000 | - | - | Restricted Stock Unit | |
| John McDonough | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.72 per share. | 20 Jul 2018 | 35,295 | 358,614 (0%) | 0% | 6.7 | 237,182 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.72 per share. | 20 Jul 2018 | 8,721 | 43,226 (0%) | 0% | 6.7 | 58,605 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.72 per share. | 20 Jul 2018 | 7,824 | 42,967 (0%) | 0% | 6.7 | 52,577 | Common Stock |
| John M. Sprague | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.72 per share. | 20 Jul 2018 | 5,619 | 11,673 (0%) | 0% | 6.7 | 37,760 | Common Stock |
| Alec Barclay | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.72 per share. | 20 Jul 2018 | 7,824 | 27,155 (0%) | 0% | 6.7 | 52,577 | Common Stock |
| John McDonough | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2018 | 108,696 | 393,909 (0%) | 0% | 0 | Common Stock | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2018 | 26,847 | 51,947 (0%) | 0% | 0 | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2018 | 24,086 | 50,791 (0%) | 0% | 0 | Common Stock | |
| John M. Sprague | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2018 | 17,292 | 17,292 (0%) | 0% | 0 | Common Stock | |
| Alec Barclay | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2018 | 24,086 | 34,979 (0%) | 0% | 0 | Common Stock | |
| David B. Elsbree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2018 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| John W. Cumming | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2018 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2018 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Stanley N. Lapidus | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2018 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Michael J. Cima | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2018 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Adrian M. Jones | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 9,000 | 4,224,894 (9%) | 0% | 0 | Common Stock | |
| Alec Barclay | SVP, Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.53 per share. | 06 Jun 2018 | 4,408 | 10,893 (0%) | 0% | 8.5 | 37,600 | Common Stock |
| Alec Barclay | SVP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2018 | 13,583 | 15,301 (0%) | 0% | 0 | Common Stock | |
| John W. Cumming | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2018 | 18,000 | 18,000 (0%) | 0% | 0 | Common Stock | |
| John W. Cumming | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2018 | 18,000 | 18,000 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2018 | 18,000 | 18,000 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2018 | 18,000 | 18,000 (0%) | 0% | 0 | Common Stock | |
| Stanley N. Lapidus | None | Sale of securities on an exchange or to another person at price $ 8.87 per share. | 02 Jun 2018 | 6,000 | 32,000 (0%) | 0% | 8.9 | 53,220 | Common Stock |
| Stanley N. Lapidus | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2018 | 18,000 | 18,000 | - | - | Restricted Stock Units | |
| Stanley N. Lapidus | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2018 | 18,000 | 38,000 (0%) | 0% | 0 | Common Stock | |
| Michael J. Cima | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2018 | 18,000 | 18,000 | - | - | Restricted Stock Units | |
| Michael J. Cima | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2018 | 18,000 | 207,418 (0%) | 0% | 0 | Common Stock | |
| David B. Elsbree | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2018 | 18,000 | 68,000 (0%) | 0% | 0 | Common Stock | |
| David B. Elsbree | None | Purchase of securities on an exchange or from another person at price $ 7.65 per share. | 01 Jun 2018 | 4,225 | 10,000 (0%) | 0% | 7.6 | 32,321 | Common Stock |
| David B. Elsbree | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2018 | 18,000 | 18,000 | - | - | Restricted Stock Units | |
| John McDonough | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2018 | 434,783 | 434,783 | - | - | Performance Restricted Stock Units | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2018 | 107,386 | 107,386 | - | - | Performance Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2018 | 96,344 | 96,344 | - | - | Performance Restricted Stock Units | |
| John M. Sprague | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2018 | 69,170 | 69,170 | - | - | Performance Restricted Stock Units | |
| Alec Barclay | SVP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2018 | 96,344 | 96,344 | - | - | Performance Restricted Stock Units | |
| John McDonough | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2018 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2018 | 90,000 | 90,000 | - | - | Stock Option (Right to Buy) | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2018 | 90,000 | 90,000 | - | - | Stock Option (Right to Buy) | |
| John M. Sprague | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2018 | 225,000 | 225,000 | - | - | Stock Option (Right to Buy) | |
| John McDonough | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2018 | 33,130 | 295,964 (0%) | 0% | 0 | Common Stock | |
| John McDonough | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.53 per share. | 09 Feb 2018 | 10,751 | 285,213 (0%) | 0% | 8.5 | 91,706 | Common Stock |
| John McDonough | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 4.28 per share. | 09 Feb 2018 | 6,292 | 262,834 (0%) | 0% | 4.3 | 26,930 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.53 per share. | 09 Feb 2018 | 5,312 | 25,100 (0%) | 0% | 8.5 | 45,311 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2018 | 16,370 | 30,412 (0%) | 0% | 0 | Common Stock | |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 4.28 per share. | 09 Feb 2018 | 2,202 | 14,042 (0%) | 0% | 4.3 | 9,425 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 4.28 per share. | 09 Feb 2018 | 2,202 | 16,911 (0%) | 0% | 4.3 | 9,425 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.53 per share. | 09 Feb 2018 | 4,705 | 26,705 (0%) | 0% | 8.5 | 40,134 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2018 | 14,499 | 31,410 (0%) | 0% | 0 | Common Stock | |
| David B. Elsbree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2018 | 9,708 | 9,708 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2018 | 9,708 | 9,708 | - | - | Restricted Stock Units | |
| Adrian M. Jones | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2017 | 9,708 | 4,214,164 (11%) | 0% | 0 | Common Stock | |
| John McDonough | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 3.35 per share. | 30 Nov 2017 | 4,895 | 449,131 (1%) | 0% | 3.3 | 16,398 | Common Stock |
| John McDonough | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 3.47 per share. | 30 Nov 2017 | 9,443 | 439,688 (0%) | 0% | 3.5 | 32,767 | Common Stock |
| John McDonough | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 47,423 | 0 | - | - | Restricted Stock Units | |
| John McDonough | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 47,422 | 0 | - | - | Restricted Stock Units | |
| John McDonough | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 47,423 | 406,604 (1%) | 0% | 0 | Common Stock | |
| John McDonough | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 47,422 | 454,026 (1%) | 0% | 0 | Common Stock | |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 3.35 per share. | 30 Nov 2017 | 2,166 | 71,060 (0%) | 0% | 3.3 | 7,256 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 3.47 per share. | 30 Nov 2017 | 4,185 | 66,875 (0%) | 0% | 3.5 | 14,522 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 15,000 | 0 | - | - | Restricted Stock Units | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 15,000 | 0 | - | - | Restricted Stock Units | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 15,000 | 58,226 (0%) | 0% | 0 | Common Stock | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 15,000 | 73,226 (0%) | 0% | 0 | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 6,500 | 50,687 (0%) | 0% | 0 | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 3.47 per share. | 30 Nov 2017 | 1,820 | 54,428 (0%) | 0% | 3.5 | 6,315 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 6,500 | 0 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 6,500 | 0 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2017 | 6,500 | 57,187 (0%) | 0% | 0 | Common Stock | |
| Michael Terrence Gibbs | General Counsel | Sale of securities on an exchange or to another person at price $ 3.35 per share. | 30 Nov 2017 | 939 | 56,248 (0%) | 0% | 3.4 | 3,146 | Common Stock |
| David B. Elsbree | None | Purchase of securities on an exchange or from another person at price $ 4.11 per share. | 16 Nov 2017 | 1,500 | 5,775 (0%) | 0% | 4.1 | 6,165 | Common Stock |
| Darlene M. Deptula-Hicks | SVP & Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 3.58 per share. | 06 Jun 2017 | 4,000 | 4,000 (0%) | 0% | 3.6 | 14,320 | Common Stock |
| David B. Elsbree | None | Purchase of securities on an exchange or from another person at price $ 3.50 per share. | 06 Jun 2017 | 10,000 | 50,000 (0%) | 0% | 3.5 | 35,000 | Common Stock |
| Stanley N. Lapidus | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2017 | 20,000 | 27,058 | - | - | Stock Option (Right to Buy) | |
| Stanley N. Lapidus | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 06 Jun 2017 | 20,000 | 20,000 (0%) | 0% | 1.2 | 23,200 | Common Stock |
| John McDonough | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2017 | 11,729 | 0 | - | - | Stock Option (Right to Buy) | |
| John McDonough | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.96 per share. | 06 Jun 2017 | 21,465 | 247,353 (0%) | 0% | 2.0 | 42,071 | Common Stock |
| John McDonough | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 06 Jun 2017 | 11,729 | 225,888 (0%) | 0% | 1.2 | 13,606 | Common Stock |
| John McDonough | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 06 Jun 2017 | 16,806 | 214,159 (0%) | 0% | 1.2 | 19,495 | Common Stock |
| John McDonough | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2017 | 21,465 | 106,025 | - | - | Stock Option (Right to Buy) | |
| John McDonough | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2017 | 16,806 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 06 Jun 2017 | 4,000 | 10,411 (0%) | 0% | 1.2 | 4,640 | Common Stock |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2017 | 4,000 | 14,647 | - | - | Stock Option (Right to Buy) | |
| Michael J. Cima | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2017 | 5,000 | 53,823 | - | - | Stock Option (Right to Buy) | |
| Michael J. Cima | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.96 per share. | 06 Jun 2017 | 5,000 | 189,418 (0%) | 0% | 2.0 | 9,800 | Common Stock |
| Michael Terrence Gibbs | General Counsel | Purchase of securities on an exchange or from another person at price $ 3.51 per share. | 06 Jun 2017 | 1,000 | 10,431 (0%) | 0% | 3.5 | 3,510 | Common Stock |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.48 per share. | 06 Jun 2017 | 3,000 | 4,667 (0%) | 0% | 0.5 | 1,440 | Common Stock |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2017 | 3,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Rahul Dhanda | SVP of Corporate Development | Purchase of securities on an exchange or from another person at price $ 3.50 per share. | 06 Jun 2017 | 1,000 | 5,667 (0%) | 0% | 3.5 | 3,500 | Common Stock |
| Joanne Spadoro | Chief Operations Officer | Purchase of securities on an exchange or from another person at price $ 3.50 per share. | 06 Jun 2017 | 5,000 | 5,589 (0%) | 0% | 3.5 | 17,500 | Common Stock |
| David B. Elsbree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2017 | 18,000 | 18,000 | - | - | Restricted Stock Units | |
| John W. Cumming | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2017 | 18,000 | 18,000 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2017 | 18,000 | 18,000 | - | - | Restricted Stock Units | |
| Stanley N. Lapidus | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2017 | 18,000 | 18,000 | - | - | Restricted Stock Units | |
| Michael J. Cima | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2017 | 18,000 | 18,000 | - | - | Restricted Stock Units | |
| Adrian M. Jones | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2017 | 18,000 | 4,175,240 (13%) | 0% | 0 | Common Stock | |
| Michael J. Cima | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 05 May 2017 | 1,400 | 184,418 (0%) | 0% | 0 | Common Stock | |
| Darlene M. Deptula-Hicks | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2017 | 175,000 | 175,000 | - | - | Stock Option (Right to Buy) | |
| David B. Elsbree | None | Purchase of securities on an exchange or from another person at price $ 5.97 per share. | 15 Mar 2017 | 10,000 | 40,000 (0%) | 0% | 6.0 | 59,700 | Common Stock |
| David P. Harding | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 17,500 | 17,500 | - | - | Restricted Stock Units | |
| David P. Harding | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| John McDonough | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 50,000 | 50,000 | - | - | Restricted Stock Units | |
| John McDonough | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 17,500 | 17,500 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 17,500 | 17,500 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Rahul Dhanda | SVP of Corporate Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Rahul Dhanda | SVP of Corporate Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 17,500 | 17,500 | - | - | Restricted Stock Units | |
| Shawn Lynch | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 17,500 | 17,500 | - | - | Restricted Stock Units | |
| Shawn Lynch | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Joanne Spadoro | Chief Operations Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 17,500 | 17,500 | - | - | Restricted Stock Units | |
| Joanne Spadoro | Chief Operations Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2017 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| John McDonough | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Nov 2016 | 94,845 | 94,845 | - | - | Restricted Stock Units | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Nov 2016 | 30,000 | 30,000 | - | - | Restricted Stock Units | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Nov 2016 | 13,000 | 13,000 | - | - | Restricted Stock Units | |
| Rahul Dhanda | SVP of Corporate Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Nov 2016 | 10,000 | 10,000 | - | - | Restricted Stock Units | |
| Seymour E. Liebman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Sep 2016 | 66,176 | 66,176 | - | - | Stock Option (right to buy) | |
| Joanne Spadoro | Chief Operations Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Sep 2016 | 146,600 | 146,600 | - | - | Stock Option (Right to Buy) | |
| Rahul Dhanda | SVP of Corporate Development | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Jun 2016 | 3,589 | 0 | - | - | Common Stock | |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jun 2016 | 3,589 | 3,589 | - | - | Common Stock | |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jun 2016 | 3,589 | 31,705 | - | - | Stock Option (Right to Buy) | |
| Stanley N. Lapidus | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2016 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| John W. Cumming | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2016 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| Harry W. Wilcox | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2016 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| David B. Elsbree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2016 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| Joshua H. Bilenker | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2016 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| Michael J. Cima | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2016 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| Shawn Lynch | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2016 | 146,600 | 146,600 | - | - | Stock Option (Right to Buy) | |
| Rahul Dhanda | SVP of Corporate Development | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Mar 2016 | 4,647 | 0 | - | - | Common Stock | |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2016 | 4,647 | 4,647 | - | - | Common Stock | |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2016 | 2,941 | 0 | - | - | Stock Option (Right to Buy) | |
| Rahul Dhanda | SVP of Corporate Development | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Mar 2016 | 2,941 | 0 | - | - | Common Stock | |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2016 | 4,647 | 0 | - | - | Stock Option (Right to Buy) | |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2016 | 2,941 | 2,941 | - | - | Common Stock | |
| Rahul Dhanda | SVP of Corporate Development | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 15 Mar 2016 | 13,770 | 0 | - | - | Common Stock | |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2016 | 13,770 | 0 | - | - | Stock Option (Right to Buy) | |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2016 | 13,770 | 13,770 | - | - | Common Stock | |
| Rahul Dhanda | SVP of Corporate Development | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 14 Mar 2016 | 2,700 | 0 | - | - | Common Stock | |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2016 | 2,700 | 2,700 | - | - | Common Stock | |
| Rahul Dhanda | SVP of Corporate Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2016 | 2,700 | 13,770 | - | - | Stock Option (Right to Buy) | |
| Adrian M. Jones | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2016 | 66,176 | 66,176 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John McDonough | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2016 | 133,334 | 133,334 | - | - | Stock Option (Right to Buy) | |
| Sarah O. Kalil | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2016 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2016 | 58,800 | 58,800 | - | - | Stock Option (Right to Buy) | |
| Michael A. Pfaller | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2016 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Michael Terrence Gibbs | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2016 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Andrew N. Schiff | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 Dec 2015 | 307,692 | 2,830,992 | - | - | Common Stock | |
| David B. Elsbree | None | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Dec 2015 | 22,222 | 27,778 | - | - | Employee Stock Option (right to buy) | |
| David B. Elsbree | None | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Dec 2015 | 7,189 | 8,987 | - | - | Employee Stock Option (right to buy) | |
| David B. Elsbree | None | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Dec 2015 | 5,882 | 11,765 | - | - | Employee Stock Option (right to buy) | |
| David B. Elsbree | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 Dec 2015 | 10,000 | 30,000 | - | - | Common Stock | |
| Thomas J. Carella | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 08 Dec 2015 | 700,000 | 4,157,240 | - | - | Common Stock | |
| David P. Harding | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Oct 2015 | 146,600 | 146,600 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2015 | 2,000 | 36,235 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2015 | 2,000 | 6,411 | - | - | Common Stock | |
| David B. Elsbree | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Aug 2015 | 75 | 4,275 | - | - | Common Stock | |
| Michael J. Cima | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Aug 2015 | 1,000 | 183,018 | - | - | Common Stock | |
| Maurice L. Castonguay | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2015 | 146,000 | 146,000 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2015 | 2,000 | 18,588 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2015 | 2,000 | 6,411 | - | - | Common Stock | |
| Thomas J. Lowery | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 10 Jul 2015 | 2,000 | 4,411 | - | - | Common Stock | |
| Stanley N. Lapidus | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2015 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| John W. Cumming | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2015 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| Harry W. Wilcox | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2015 | 17,647 | 0 | - | - | Stock Option (Right to Buy) | |
| David B. Elsbree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2015 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Carella | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2015 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| Joshua H. Bilenker | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2015 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| Michael J. Cima | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2015 | 17,647 | 17,647 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jun 2015 | 1,000 | 18,647 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Lowery | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jun 2015 | 1,000 | 5,411 | - | - | Common Stock |